Last edited by Karr
Monday, August 3, 2020 | History

3 edition of Chromosome 12 Aberrations in Human Solid Tumors found in the catalog.

Chromosome 12 Aberrations in Human Solid Tumors

Jorn Bullerdiek

Chromosome 12 Aberrations in Human Solid Tumors

Cytogenetics and Molecular Genetics

by Jorn Bullerdiek

  • 331 Want to read
  • 14 Currently reading

Published by Springer-Verlag Telos .
Written in English


The Physical Object
Number of Pages194
ID Numbers
Open LibraryOL7447132M
ISBN 100387557598
ISBN 109780387557595

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field. Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations. ADVERTISEMENTS: Aberration alters the chromosome structure but do not involve a change in chromosome number. The mechanics signify chiefly a rearrangement through loss, gain or reallocation of chromosomal segments. In normal course of cell-division cycle, the chromosomes duplicate and segregate in an orderly manner. The sequence of gene loci in the chromosome .

  Chapter in an edited book. 1. Meltzer PS, Kallioniemi A, Trent JM. Chromosome alterations in human solid tumors. In: Vogelstein B, Kinzler KW, editors. In analogy, most malignant tumours exhibit both structural and numerical chromosome abnormalities (Mitelman Database of Chromosome Aberrations in Cancer ). However, in many low-grade mesenchymal and neuroglial tumours, BFB events involving telomeric associations and ring chromosomes are seen at mitosis, in the absence of major numerical.

Edwards AA (), The use of chromosomal aberrations in human lymphocytes for biological dosimetry, Radiation Research , SS Edwards AA (), Modeling radiation-induced chromosome aberrations, International Journal of Radiation Biol @article{osti_, title = {Screening for somatic mutations of the neurofibromatosis genes in nervous system and other solid tumors}, author = {Rangaratnam, S and Narod, S and Ruttledge, M}, abstractNote = {Von Recklinghausen neurofibromatosis (NF1) and neurofibromatosis type 2 (NF2) are autosomal dominant inherited disorders which predispose carriers to various benign .


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Chromosome 12 Aberrations in Human Solid Tumors by Jorn Bullerdiek Download PDF EPUB FB2

Chromosome 12 Aberrations in Human Solid Tumors: Medicine & Health Science Books @ Chromosome 12 Aberrations in Human Solid Tumors Cytogenetics and Molecular Genetics. Editors (view affiliations) Numerical Chromosome 12 Analysis of Carcinoma In Situ and Invasive Germ Cell Tumors of the Adult Testis: A Study Based on the Simultaneous Application of Interphase Cytogenetics and Immunohistochemistry on Tissue Sections.

Chromosome 12 Aberrations in Human Solid Tumors Cytogenetics and Molecular Genetics. Editors: Bullerdiek, Jörn, Bartnitzke, Sabine (Eds.) Free Preview. Comparative gene mapping: human chromosome 12 and mouse chromosome 15 / H.

Hameister [and others] --Molecular oncology of 12q / B. Rommel, J. Bullerdiek, W. Schloot --Gene analysis: methods and facts --Cell lines from tumors showing 12q aberrations / B. Kazmierczak [and others] --Analysis of DNA from a specific chromosome region / N. Get this from a library. Chromosome 12 Aberrations in Human Solid Tumors: Cytogenetics and Molecular Genetics.

[J Bullerdiek; S Bartnitzke] -- Researchers involved in the cytogenetics and molecular genetics of human tumors will welcome this comprehensive overview of the type of aberrations that chromosome 12 presents in human solid tumors. Suijkerbuijk R.F.

et al. () Chromosome 12 Aberrations in Human Germ Cell Tumors: A Fluorescence In Situ Chromosome 12 Aberrations in Human Solid Tumors book Inventory. In: Bullerdiek J., Bartnitzke S. (eds) Chromosome 12 Aberrations in Human Solid : R. Suijkerbuijk, R. Sinke, L. Looijenga, B.

de Jong, J. Oosterhuis, J. Cassiman, A. The concept of errors in cell division resulting in abnormal chromosome complements responsible for cancer development was first proposed by Boveri in 14 The landmark observation by Tjio and Levan in 15 confirmed the presence of 46 chromosomes in normal human cells.

InNowell and Hungerford16, 17 identified a recurrent deleted chromosome in patients with Cited by:   CHROMOSOME 8. Alterations of human chromosome 8p have been commonly detected in many tumor types[].Some studies have shown that loss of 8p is associated with the advance of tumors, and plays an important role in the tumor progression of many tumors including colorectal[], bladder[14,15], breast[] and liver cancers[].Recently, some studies have Cited by:   The aberrations of chromosome 12 which the e-book bargains with are very common chromosomal changes in human tumors occuring in widespread benign mesenchymal tumors, corresponding to uterine leiomyomas and lipomas, and in tumors of epithelial foundation, reminiscent of pleomorphic adenomas of the salivary glands/5(39).

4 Cancer Ploidy and Chromosome Aberration Rates. Solid tumors with a chromosome number between triploid (n = 69) and tetraploid (n = 92) have been estimated to occur in some 30 % of all epithelial cancers (Storchova and Kuffer ).As it is unlikely that chromosome missegregation alone occurs at sufficiently high rates to explain how cancer cells achieve such pseudo Cited by: Chromosome aberrations in solid tumors Donna G Albertson 1,2, Colin Collins 1,2, Frank McCormick 1,3 & Joe W Gray 2,4 Chromosome aberrations in human solid tumors are hallmarks of gene deregulation and genome instability.

This review summarizes current knowledge regarding aberrations, discusses their functional importance, suggests mechanisms. Chromosomal aberrations are a common feature of human cancers, are more pronounced in solid tumors than hematologic cancers and occur with consistency in malignant melanomas 11.

Patterns of Chromosomal Aberrations in Solid Tumors recommended to screen AO patients for these chromosom al aberrations (Anderson and Gilbert ; Polivka et al. Numerical disorders. This is called aneuploidy (an abnormal number of chromosomes), and occurs when an individual either is missing a chromosome from a pair (monosomy) or has more than two chromosomes of a pair (trisomy, tetrasomy, etc.).

An example of trisomy in humans is Down syndrome, which is a developmental disorder caused by an extra copy of chromosome. Stark, B, Mor, C, Jeison, M, et al.

Additional chromosome 1q aberrations and der(16)t(1;16), correlation to the phenotypic expression and clinical behavior of the Ewing family of tumors. J Neurooncol ; 3 – by: 1. DISCUSSION It is an important result of the last decade of chromosome studies in human tumors that benign tumors can show typical or even specific chromosome aberrations as well.

The first specific aberration found in a benign tumor was monosomy 22 in meningiomas [11, Cited by: XVII- Primary and secondary chromosome aberrations.

Secondary aberrations may enable survival of an otherwise lethal unbalanced product. Examples: Additional isochromosomes deriving from a trisomy. - Correction of trisomy through uniparental disomy. - Secondary structural aberrations with loss of a chromosomal segment following a trisomy.

The first three editions of this acclaimed book presented a much-needed conceptual synthesis of this rapidly moving field.

Now, Cancer Cytogenetics, Fourth Edition, offers a comprehensive, expanded, and up-to-date review of recent dramatic advances in this area, incorporating a vast amount of new data from the latest basic and clinical investigations.5/5(2). Research on DNA and chromosome aberrations focuses on cancer genetics and epigenetics.

Topics include regulation of gene expression; DNA damage from exposure to chemical, physical, and endogenous agents; mechanisms of DNA damage signaling and DNA repair; and genomic instability and related molecular, cytogenetic, and chromosomal effects during tumor formation.

Targeted Therapies for Solid Tumors A Handbook for Moving Toward New Frontiers in Cancer Treatment C. Cancer Treatment. Follow. 4 years ago | 0 view. Targeted Therapies for Solid Tumors A Handbook for Moving Toward New. ferent types of spindle cell tumors cannot always be distinguished from one another morphologically, particularly when poorly differentiated.

Synovial sarcoma, myxoid liposarcoma, and extraskeletal myxoid chondrosarcoma are all associated with specific translocations—t(X;18)(p;q) in synovial sarcoma (); t(12;16)(q13;p11) in myxoid. Boveri proposed that cancer originates in a single cell by mitotic disturbances resulting in chromosome aberrations.

Through subsequent cell divisions, this acquired genetic change is propagated to all daughter cells. And as a consequence, all cells in a cancer carry the genetic abnormality that initiated this process.

This remarkably prescient idea still today .(2) Numerical and structural aberrations of chromosome 1 have been found in many solid tumors (Atkin ). (3) Aber- rations of chromosomes 1 and 18 have been previously noted in TC and TC by in situ hybridization with subregional DNA probes specific for lq12 and the pericentromeric hetero.